עוד קצת חומר על ההורמון הזה שנמצא בתוך השתן, אל תגידו שזה לא מעניין.. אם אין לכם כוח אז לפחות תקראו את המודגש, מחקר שנעשה ב- 2006.
Studies have shown that DHEA is useful in patients with
systemic lupus erythematosus. An application of the evidence was discussed by the U.S.
Food and Drug Administration in 2001 and is available online.
[4] This review also shows that
cholesterol and other serum lipids decrease with the use of DHEA (mainly a decrease in HDL-C and triglycerides can be expected in women, p110).
DHEA supplementation has been studied as a treatment for
Alzheimer's disease, but was found to be ineffective.
[5] Some small
placebo-controlled randomized clinical trial studies have found long-term supplementation to improve mood and relieve
depression[6][7] or to decrease
insulin resistance.
[8] However, a larger
placebo-controlled randomized clinical trial reported in the
New England Journal of Medicine in 2006 found that DHEA supplementation in
elderly men and women had no beneficial effects on body composition, physical performance,
insulin sensitivity, or
quality of life.
[9]
In contrast to the non-beneficial effects of DHEA on memory in the elderly, a randomised UK study
[10] found that a 7-day course of DHEA (150 mg twice daily) improved
episodic memory in healthy young men. In this study, DHEA was also shown to improve subjective mood and decrease evening
cortisol concentration, which is known to be elevated in
depression[11]. The effect of DHEA on memory appeared to be related to an early activation of the
anterior cingulate cortex (ACC) and it was suggested this was due to neuronal recruitment of the steroid sensitive ACC that may be involved in pre-hippocampal memory processing.
DHEA supplements are sometimes used as muscle-building or performance-enhancing drugs by athletes. However, a randomized placebo-controlled trial found that DHEA supplementation had no effect on lean body mass, strength, or
testosterone levels.
[12]
A 1986 study found that a higher level of
endogenous DHEA, as determined by a single measurement, correlated with a lower risk of death or
cardiovascular disease.
[13] However, a more recent 2006 study found no correlation between DHEA levels and risk of cardiovascular disease or death in men.
[14] A 2007 study found the DHEA restored
oxidative balance in
diabetic patients, reducing t
ue levels of
pentosidine—a
biomarker for
advanced glycation endproducts.
[15]
Some
in vitro studies have found DHEA to have an anti-proliferative or
apoptotic effect on cancer cell lines.
[16][17][18] The clinical significance of these findings, if any, is unknown. Higher levels of DHEA, in fact, have been correlated with an
increased risk of developing
breast cancer in both
pre- and postmenopausal women.
[19][20]
An anonymous 2002 review, in the French journal Prescrire, concluded: DHEA plasma levels are so low in most animals that they are difficult to measure, hindering studies on DHEA and aging. DHEA had not yet, at the time of writing, been linked to any specific health disorder. Side effects are linked to its androgenic effects, unfavorable lipid metabolism effects, and "possible growth-stimulating effect" on hormone dependent malignancies. "In practice, there is currently no scientific reason to prescribe DHEA for any purpose whatsoever."
[21]
A 2005 study, measured serum DHEA in 206 men with type-2 diabetes, and found an inverse relationship between serum DHEA and carotid atherosclerosis in men. The authors say the study "supports the notion that DHEA, which is sold in increasing amount as a food supplement, is atheroprotective in humans, and that androgen replacement therapy should be considered for men with hypogonadism."
[22]
A 2006 study supplemented DHEA to men of average 65 years of age, and found that the men experienced significant increases in testosterone and
cGMP (Cyclic guanosine monophosphate), and significant decreases in low-density liprotein (LDL). The authors say that the "findings...suggest that chronic DHEA supplementation would exert antiatherogenic effects, particularly in elderly subjects who display low circulating levels of this hormone."
[23]
A 2008 study in the Journal of the American Geriatrics Society, June 2008, measured serum DHEA in 940 men and women ranging from age 21 to 88, following them from 1978 until 2005. The researches found that low levels of DHEA-s showed a significant association with shorter lifespan and that higher DHEA-s levels are a "strong predictor" of longevity in men, even after adjusting for age, blood pressure, and plasma glucose. No relationship was found between serum DHEA and longevity for women during the study period. The study did not find a significant difference in longevity until the 15-year follow-up point, which the researchers note may explain why some past research that followed men for less duration found no relationship.
[24]
[edit] Disputed effects